NAKAJIMA, Kenichi, MD, PhD, Professor, Department of Functional Imaging and Artificial Intelligence, Kanazawa Univeristy

Present Position: My research activities include:


Our major works published in Journals: [PDF file available, to take contact-]

  1. Nakajima K, Mizokami A, Matsuyama H, Ichikawa T, Kaneko G, Takahashi S, Shiina H, Horikoshi H, Hashine K, Sugiyama Y, Miyao T, Kamiyama M, Harada K, Ito A, PROSTAT-BSI investigators.  Prognosis of patients with prostate cancer and bone metastasis from the Japanese Prostatic Cancer Registry of Standard Hormonal and Chemotherapy Using Bone Scan Index cohort study. Int J. Urol 2021; 28: 955-963 
  2. Watanabe S, Nakajima K, Wakabayashi H, Yoneyama H, Yoshida S, Komatsu J, Konishi T, Inaki A, Kinuya S.  Volumetric evaluation of 99mTc-pyrophosphate SPECT/CT for transthyretin cardiac amyloidosis: Methodology and correlation with cardiac functional parameters. J Nucl Cardiol 2021; Online ahead of print.
  3. Saito S., Nakajima K, Edenbrandt L, Enqvist O, Ulen J, Kiunya S.  Convolutional neural network-based automatic heart segmentation and quantitation in 123I-metaiodobenzylguanidine SPECT imaging. EJNMMIRes 2021; 11: 105
  4. Shibutani T, Nakajima K, Yoneyama H, Konishi T, Okuda K, Onoguchi M, Kinuya S. The utility of heart-to-mediastinum ratio using a planar image created from IQ-SPECT with Iodine-123 meta-iodobenzylguanidine. J Nucl Cardiol. 2021 Dec;28(6):2569-2577.
  5. Sakatani T, Nakajima K, Nishimura T.   Cardiovascular event risk estimated by myocardial perfusion SPECT combined with clinical data. J Cardiol 2021 Oct 30; Online ahead of print S0914-5087(21)00275-6.
  6. Nakajima K, Wakabayashi H. Value of combined perfusion and metabolic tracers versus stress-rest perfusion imaging for coronary heart disease. J Nucl Cardiol 2021; 28, 3081-3084
  7. Nakajima K.  Triglyceride deposit cardiomyovasculopathy: How to recognise a new disease entity. Heart 2021;107: 93-95
  8. Nakajima K, Nakata T, Doi T, Tada H, Maruyama K. Machine learning-based risk model using 123 I-metaiodobenzylguanidine to differentially predict modes of cardiac death in heart failure. J Nucl Cardiol 2022;29:190-201. doi: 10.1007/s12350-020-02173-6. Online ahead of print )   
  9.  Okuda K, Nakajima K, Kitamura C, Kirihara Y, Hashimoto M, Kinuya S. Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity. Sientific Reports 2020; 10; Article number: 21834
  10. Verschure DO, Poel E, De Vincentis G, Frantellizzi V, Nakajima K, Gheysens O, de Groot JR, Verberne HJ.  The relation between cardiac 123I-mIBG scintigraphy and functional response 1 year after CRT implantation. Eur Heart J Cardiovasc Imaging 2021; 22: 49-57
  11.  Nakajima K, Okuda K, Komatsu J. What does diagnostic threshold mean? Deterministic and probabilistic considerations. J Nucl Cardiol 2021; 28:1702-1706
  12. Shibutani T, Onoguchi M, Naoi Y, Konishi T, Tatami R, Nakajima K. The usefulness of SwiftScan technology for bone scintigraphy using a novel anthropomorphic phantom. Sientific Reports 2021; 11; Article number: 2644
  13. Shibutani T, Onoguchi M, Yoneyama H, Konishi T, Nakajima K. Performance of SwiftScan planar and single photon emission computed tomography technology using low-energy high-resolution and sensitivity collimator. Nucl Med Commun. 2021 Mar 18. (Epub ahead of print)
  14. Verschure DO, Nakajima K, Verberne HJ.  123I-mIBG in the risk stratification of sudden cardiac death in chronic heart failure. Nuclear Cardiology - Basic and Advanced Concepts in Clinical Practice (Claudio Tinoco Mesquita Maria Fernanda Rezende Ed), p567-585
  15. Kikuchi A, Wada N, Kawakami T, Nakajima K, Yoneyama H.  A myocardial extraction method using deep learning for 99mTc myocardial perfusion SPECT images: A basic study to reduce the effects of extra-myocardial activity. Comput Biol Med 2021 Dec 23;141:105164. doi: 10.1016/j.compbiomed.2021.105164.
  16.  Nakajima K, Yoneyama H, Slomka P. Beware the pitfalls of beauty: High-quality myocardial images with resolution recovery. J Nucl Cardiol 2021; 28; 245-248
  17. Nakajima K, Okuda K, Maruyama K. Demystifying dyssynchrony for diagnosis and prognosis: Tips for measuring heterogeneous phase distribution. J Nucl Cardiol 2021;28: 1064-1067 (Epub ahead of print) doi:10.1007/s12350-019-01855-0
  18. Okuda K, Nakajima K. What does entropy reveal in phase analysis of myocardial perfusion SPECT? J Nucl Cardiol 2021; 28: 172-174 (Epub ahed of print)
  19. Nakajima K, Nakamura S, Hase H, Takeishi Y, Nishimura S, Kawano Y, NishimuraT. Risk stratification based on J-ACCESS risk models with myocardial perfusion imaging: Risk versus outcomes of patients with chronic kidney disease. J Nucl Cardiol 2020; 27: 41-50; Epub ahead of print.
  20. Nakajima K, Kaneko G, Takahashi S, Matsuyama H, Shiina H, Ichikawa T, Horikoshi H, Hashine K, Sugiyama Y, Miyao T, Kamiyama M, Harada K, Ito A and Atsushi Mizokami. Role of bone scan index in the prognosis and effects of therapy on prostate cancer with bone metastasis: Study design and rationale for the multicenter Prostatic Cancer Registry of Standard Hormonal and Chemotherapy Using Bone Scan Index (PROSTAT-BSI) study. Int J Urol 2021; 25: 492-499 doi: 10.1111/iju.13556 [Download]
  21. Matsuo S, Nakajima K, Takeishi Y, Nishimura T. Prognostic value of normal stress myocardial perfusion imaging and ventricular function in Japanese patients with chronic kidney disease: a study based on the J-ACCESS-3 database. Eur J Nucl Med Mol Imaging 2018; 45: 1101-1107 
  22. Nakajima K, Okuda K, Watanabe S, Matsuo S, Kinuya S, Toth K, Edenbrandt L. Artificial neural network retrained to detect myocardial ischemia using a Japanese multicenter database. Ann Nucl Med 2018; 32; 303-310 doi: 10.1007/s12149-018-1247-y. [Download]
  23. Nakajima K, Nakata T, Doi T, Kadokami T, Matsuo S, Konno T, Yamada T, Jacobson AF. Validation of 2-year 123I-meta-iodobenzylguanidine-based cardiac mortality risk model in chronic heart failure. Eur Heart J Cardiovasc Imaging. 2018; 19: 749-756 [Download]
  24. Nakajima K, Okuda K, Matsuo S, Wakabayashi H, Kinuya S. Is 123I-metaiodobenzylguanidine heart-to-mediastinum ratio dependent on age? From Japanese Society of Nuclear Medicine normal database. Ann Nucl Med 2018;32 (3):175-181. doi: 10.1007/s12149-018-1231-6. [Download].
  25. Nakajima K, Kudo T, Nakata T, Kiso K, Kasai T, Taniguchi Y, Matsuo S, Momose M, Nakagawa M, Sarai M, Hida S, Tanaka H, Yokoyama K, Okuda K, Edenbrandt L. Diagnostic accuracy of an artificial neural network compared with statistical quantitation of myocardial perfusion images: a Japanese multicenter study. Eur J Nucl Med Mol Imaging. 2017; 44: 2280 - 2289. doi: 10.1007/s00259-017-3834-x[Download]
  26. Nakajima K, Okuda K, Momose M, Matsuo S, Kondo C, Sarai M, Shibutani T, Onoguchi M, Shimizu T, Vija HA. IQ•SPECT technology and its clinical applications using multicenter normal databases. Ann Nucl Med 2017; 31 (9): 649-659. doi: 10.1007/s12149-017-1210-3. [Download]
  27. Verschure DO, de Groot JR, Mirzaei S, Gheysens O, Nakajima K5, van Eck-Smit BLF, Aernout Somsen G, Verberne HJ. Cardiac 123I-mIBG scintigraphy is associated with freedom of appropriate ICD therapy in stable chronic heart failure patients. Int J Cardiol. 2017 Aug 25. doi: 10.1016/j.ijcard.2017.08.003. [Epub ahead of print]
  28. Nakajima K, Okuda K, Yokoyama K, Yoneyama T, Tsuji S, Oda H, Yoshita M, Kubota K. Cross calibration of 123I-meta-iodobenzylguanidine heart-to-mediastinum ratio with D-SPECT planogram and Anger camera. Ann Nucl Med 2017; 31(8):605-615(Epub ahead of print - Download)
  29. [Editorial] Nakajima K, Okuda K, Matsuo S, Slomka P. Making the invisible visible - Phase dyssynchrony as a possible new marker of prognosis. J Nucl Cardiol 2017 May 25. doi: 10.1007/s12350-017-0929-5 [Download]
  30. Nakajima K, Edenbrandt L, Mizokami A. Bone scan index: a new biomarker for bone metastasis in patients with prostate cancer. Int J Urol. 2017; 24(9): 668-673. doi: 10.1111/iju.13386. Epub 2017 May 26 [Download]
  31. Nakajima K, Verschure DO, Okuda K, Verberne HJ. Standardization of 123I-meta-iodobenzylguanidine myocardial sympathetic activity imaging: phantom calibration and clinical applications. Clin Transl Imaging 2017 2017;5(3):255-263. doi: 10.1007/s40336-017-0230-2 - Download)
  32. Verschure DO, Poel E, Nakajma K, Okuda K, Van Eck-Smit BLF, Somsen GA, Verberne HJ. A European myocardial 123I-mIBG cross-calibration phantom study. J Nucl Cardiol 2017 (Epub ahead of Print - DOI 10.1007/s12350-017-0782-6 Download)
  33. Nakajima K, Scholte A, Nakata T, Dimitriu-Leen AC, Chikamori T, Vitola J, Yoshinaga K.Cardiac sympathetic nervous system imaging with 123I-meta-iodobenzylguanidine: Perspectives from Japan and Europe. J Nucl Cardiol 2017; 24(3):952-960 (DOI 10.1007/s12350-017-0818-y)
  34. Nakamura S, Kawano Y, Nakajima K, Hase H, Joki N, Hatta T, et al. Prognostic study of cardiac events in Japanese patients with chronic kidney disease using ECG-gated myocardial Perfusion imaging: Final 3-year report of the J-ACCESS 3 study. J Nucl Cardiol 2017 (Epub ahead of Print - DOI 10.1007/s12350-017-0880-5)
  35. [Editorial] Nakajima K, Matsunari I, Jacobson AF. I-123 metaiodobenzylguanidine innervation imaging as a tool for norepinephrine transporter research: A possible application for genetic analysis in heart failure. J Nucl Cardiol (Epub ahead of print. doi:10.1007/s12350-016-0739-1 Download) )
  36. Nakajima K. 123I-meta-iodobenzylguanidine imaging: From standardization to mortality risk models in heart failure. Ann Nucl Cardiol 2016; 2: 152-156. Download.
  37. Nakajima K, Yamada M. 123I-meta-iodobenzylguanidine sympathetic imaging: Standardization and application to neurological diseases. Chonnam Med J 2016; 52:145-150 Download.
  38. Nakajima K, Nakata T, Matsuo S, Jacobson AF. Creation of mortality risk charts using 123I meta-iodobenzylguanidine heart-to-mediastinum ratio in patients with heart failure: two- and five-year risk models. Eur Heart J Cardiovasc Imaging 20162016;17(10):1138-45 (Download)
  39. Nakajima K, Matsumoto N, Kasai T, Matsuo S, Kiso K, Okuda K. Normal values and standardization of parameters in nuclear cardiology: Japanese Society of Nuclear Medicine working group database. Ann Nucl Med 2016; 30: 188-99 Download
  40. Nakajima K, Okuda K, Matsuo S, Kiso K, Kinuya S, Garcia EV. Comparison of phase dyssynchrony analysis using gated myocardial perfusion imaging with four software programs: based on the Japanese Society of Nuclear Medicine working group normal database. J Nucl Cardiol 2017;24(2):611-621 Download
  41. Nakajima K, Okuda K, Matsuo S, Agostini D. The time has come to standardize 123I-MIBG heart-to-mediastinum ratios including planar and SPECT methods. Eur J Nucl Med Mol Imaging 2016; 43: 386-8 Download
  42. Okuda K, Nakajima K, Sugino S, Kirihara Y, Matsuo S, Taki J, Hashimoto M, Kinuya S. Development and validation of a direct-comparison method for cardiac 123I-metaiodobenzylguanidine washout rates derived from late 3-hour and 4-hour imaging. Eur J Nucl Med Mol Imaging 2016; 43: 319-25
  43. Nakajima K, Jacobson A. 123I-MIBG: are there any additional roles in clinical practice of heart failure? Ann Nucl Cardiol 2015; 1: 127-131 Download
  44. Nakajima K, Nakata T. Cardiac 123I-MIBG imaging for clinical decision making: 22-year experience in Japan. J Nucl Med 2015; Suppl 4:11S-19S Download
  45. Nakajima K, Okuda K, Yoshimura M, Matsuo S, Wakabayashi H, Imanishi Y, Kinuya S. Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variation. J Nucl Cardiol 2014 Oct;21(5):970-8 (Download).
  46. Nakajima K, Matsuo S, Wakabayashi H , Yokoyama K, Bunko H, Okuda K, Kinuya S, Nyström K, Edenbrandt L. Diagnostic performance of artificial neural network for detecting ischemia in myocardial perfusion imaging. Circ J 2015; 79:1549-1556.
  47. Nakajima K, Nakata T, Yamada T, Yamashina S, Momose M, Kasama S, Matsui T, Matsuo S, Travin MI, Jacobson AF. A prediction model for 5-year cardiac mortality in patients with chronic heart failure using 123I-metaiodobenzylguanidine imaging.Eur J Nucl Med Mol Imaging 2014;41(9):1673-82 [Epub ahead of print] [Download]
  48. Nakajima K, Nakajima Y, Horikoshi H, Ueno M, Wakabayashi H, Shiga T, Yoshimura M, Ohtake E, Sugawara Y, Matsuyama H, Edenbrandt L. Enhanced diagnostic accuracy for quantitative bone scan using an artificial neural network system: a Japanese multi-center database project. EJNMMI Res 2013; 3 (1):83 [Download] [PDF]
  49. Edenbrandt L, Höglund P, Frantz S, Hasbak P, Johansen A, Johansson L, Kammeier A, Lindner O, Lomsky M, Matsuo S, Nakajima K, Nyström K, Olsson E, Sjöstrand K, Svensson SE, Wakabayashi H, Trägårdh E. Area of ischemia assessed by physicians and software packages from myocardial perfusion scintigrams. BMC Med Imaging. 2014 Jan 31;14:5. doi: 10.1186/1471-2342-14-5. [Download]
  50. Johansson L, Edenbrandt L, Nakajima K, Lomsky M, Svensson SE, Trägårdh E. Computer-aided diagnosis system outperforms scoring analysis in myocardial perfusion imaging. J Nucl Cardiol. 2014;21(3):416-23
  51. Matsuo S, Nakajima K, Kinuya S, Yamagishi M. Diagnostic utility of 123I-BMIPP imaging in patients with Takotsubo cardiomyopathy. J Cardiol. 2013 Dec 9 (in press)
  52. Yamashita S, Yokoyama K, Onoguchi M, Yamamoto H, Hiko S, Horita A, Nakajima K. Feasibility of deep-inspiration breath-hold PET/CT with short-time acquisition: detectability for pulmonary lesions compared with respiratory-gated PET/CT. Ann Nucl Med. 2013 Oct 23. (Open Access)
  53. Nanasato M, Nakajima K, Fujita H, Zen K, Kohsaka S, Hashimoto A, Moroi M, Fukuzawa S, Chikamori T, Nishimura S, Yamashina A, Kusuoka H, Hirayama A, Nishimura T. Rationale and design of J-ACCESS 4: Prognostic impact of reducing myocardial ischemia identified using ECG-gated myocardial perfusion SPECT in Japanese patients with coronary artery disease. J Cardiol. 2013 Sep 3. doi:pii: S0914-5087(13)00231-1
  54. Nakata T, Nakajima K, Yamashina S, Yamada T, Momose M, Kasama S, Matsui T, Matsuo S, Travin MI, Jacobson AF. A pooled analysis of multicenter cohort studies of 123I-mIBG imaging of sympathetic innervation for assessment of long-term prognosis in heart failure. JACC Cardiovasc Imaging. 2013;6 (7): 772-784. doi: 10.1016/j.jcmg.2013.02.007.
  55. Wakabayashi H, Nakajima K, Mizokami A, Namiki M, Inaki A, Taki J, Kinuya S. Bone scintigraphy as a new imaging biomarker: the relationship between bone scan index and bone metabolic markers in prostate cancer patients with bone metastases. Ann Nucl Med.2013; 27(9):802-7.
  56. Nakajima K, Okuda K, Nyström K, Richter J, Minarik D, Wakabayashi1 H, Matsuo S, Kinuya S, Edenbrandt L. Improved quantification of small hearts for gated myocardial perfusion imaging. Eur J nucl Med Mol Imaging 2013; 40: 1163-70. doi: 10.1007/s00259-013-2431-x. Epub 2013 Apr 30. (Download)
  57. Nakajima K, Takeishi Y, Matsuo S, Yamasaki Y, Nishimura T. Metabolic syndrome is not a predictor for cardiovascular events in Japanese patients with diabetes mellitus asymptomatic for coronary artery disease: A retrospective analysis of the J-ACCESS-2 study. J Nucl Cardiol 2013;20(2):234-41.
  58. Nakajima K, Nishimura T. Cardiovascular events in Japan: Lessons from the J-ACCESS multicenter prognostic study using myocardial perfusion imaging. Circ J 2012; 76: 1313-1321
  59. Nakajima K, Okuda K, Matsuo S, Yoshita M, Taki J, Yamada M, Kinuya S. Standardization of metaiodobenzylguanidine heart-to-mediastinum ratio using a calibration phantom: Effects of correction on normal databases and a multi-center study. Eur J Nucl Med Mol Imaging 2012;39(1):113-9
  60. Nakajima K, Matsuo S, Okuyama C, Hatta M, Tsukamoto K, Nishimura S, Yamashina A, Nishimura T. Cardiac event risk in Japanese subjects estimated using gated myocardial perfusion imaging, in conjunction with diabetes mellitus and chronic kidney disease. Circ J 2012;76: 168-175
  61. Okuda K, Nakajima K, Matsuo S, Wakabayashi H, Taki J, Kinuya S. Cause of apical thinning on attenuation-corrected myocardial perfusion SPECT. Nucl Med Commun. 2011 Nov;32(11):1033-9.
  62. Nakajima K, Matsuo S, Okuda K, Wakabayashi H, Tsukamoto K, Nishimura T. Estimation of cardiac event risk by gated myocardial perfusion imaging and quantitative scoring methods based on a multi-center J-ACCESS database. Circ J 2011; 75:10, 2417-23. (Epub)
  63. Okuda K, Nakajima K, Hosoya T, Ishikawa T, Matsuo S, Kawano M, Taki J, Kinuya S. Quantification of myocardial perfusion SPECT using freeware package (cardioBull). Ann Nucl Med. 2011 Oct;25(8):571-9
  64. Wakabayashi H, Nakajima K, Fukuoka M, Inaki A, Nakamura A, Kayano D, Kinuya S. Double-phase 131I whole body scan and 131I SPECT-CT images in patients with differentiated thyroid cancer: their effectiveness for accurate identification. Ann Nucl Med 2011 Nov;25(9):609-15
  65. Kim F, Yamada K, Inoue D, Nakajima K, Mizushima I, Kakuchi Y, Fujii H, Narumi K, Matsumura M, Umehara H, Yamagishi M, Kawano M. IgG4-related tubulointerstitial nephritis and hepatic inflammatory pseudotumor without hypocomplementemia. Intern Med. 2011;50(11):1239-44. Epub 2011 Jun 1.
  66. Okuyama C, Nakajima K, Hatta T, Nishimura S, Kusuoka H, Yamashina A, Nishimura T. Incremental prognostic value of myocardial perfusion single photon emission computed tomography for patients with diabetes and chronic kidney disease. Nucl Med Commun. 2011;32(10):913-9.
  67. Okuda K, Nakajima K, Hosoya T, Ishikawa T, Konishi T, Matsubara K, Matsuo S, Kinuya S. Semi-automated algorithm for calculating heart-to-mediastinum ratio in cardiac Iodine-123 MIBG imaging. J Nucl Cardiol. 2011;18(1):82-9
  68. Nakajima K. [Editorial] Visual versus quantitative assessment: a new viewpoint for cardiac function using motion tracking method. Circ J 2011;75: 57-8
  69. Nakajima K, Hasegawa M, Inaki A, Wakabayashi H, Hosoya T, Takehara K, Kinuya S. Esophageal transit study using a sliding sum image: Application to patients with probable and definite systemic sclerosis. Ann Nucl Med 2011;25:325-31 - Sliding Sum Imge Software for Windows PC available now.
  70. Yamasaki Y, Nakajima K, Kusuoka H, Izumi T, Kashiwagi A, Kawamori R, Shimamoto K, Yamada N, Nishimura T. Prognostic value of gated myocardial perfusion imaging for asymptomatic patients with type-2 diabetes: The J-ACCESS II investigation. Diabetes Care 2010;33(11) :2320-6
  71. Nakajima K, Matsuo S, Hasegawa M, Kinuya S, Takehara K. Identification of myocardial damage in systemic sclerosis: A nuclear cardiology approach. In: Special issue of vascular disease in systemic sclerosis. Int J Rheumatology 2010, Article ID 496509, 9 pages, 2010. doi:10.1155/2010/496509 [ Download]
  72. Matsuo S, Nakajima K, Yamasaki Y, Kashiwagi A, Nishimura T. Prognostic value of normal stress myocardial perfusion imaging and ventricular function in Japanese asymptomatic patients with type 2 diabetes. Circ J. 2010;74(9):1916-21
  73. Usui Y, Chikamori T, Nakajima K, Hida S, Yamashina A, Nishimura T. Prognostic value of post-ischemic stunning as assessed by gated myocardial perfusion single-photon emission computed tomography: a subanalysis of the J-ACCESS study. Circ J. 2010 Aug;74(8):1591-9. Epub 2010 Jun 19
  74. (JSNM working group final report/ review article) Nakajima K. Normal values for nuclear cardiology: Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function. Ann Nucl Med 2010; 24:125-135 [Download]
  75. Nakajima K, Nishimura T. Prediction of cardiac mortality and events by myocardial perfusion Imaging: Differences between Japan and American populations. In: Horizons in World Cardiovascular Research. Editors: Eleanor H. Bennington. Volume 2. 2010, Nova Science Publishers (Download).
  76. Nakajima K, Matsuo S, Kawano M, Matsumoto N, Hashimoto J, Yoshinaga K, Taki J, Okuda K. The validity of multi-center common normal database for identifying myocardial ischemia: Japanese Society of Nuclear Medicine working group database. Ann Nucl Med. 2010;24(2):99-105
  77. Watanabe S, Kahara T, Seto C, Uchiyama A, Abo H, Ishikura K, Nakajima K, Usuda R. Utility of follow-up of 131I-MIBG scintigraphy to screen pheochromocytoma. Intern Med. 2009;48(18):1711-2. Epub 2009 Sep 15.
  78. Nakajima K, Inaki A, Hiramatsu T, Hasegawa M, Fujimoto M, Takehara K, Kinuya S. Esophageal transit scintigraphy and structured questionnaire in patients with systemic sclerosis with endoscopically proven reflux esophagitis. Ann Nucl Med 2009; 23: 771-776
  79. Nakajima K, Yamasaki Y, Kusuoka H, Izumi T, Kashiwagi A, Kawamori R, Shimamoto K, Yamada N, Nishimura T. Cardiovascular events in Japanese asymptomatic patients with type 2 diabetes: A one-year interim report of a J-ACCESS 2 investigation using myocardial perfusion imaging. Eur J Nucl Med Mol Imaging 2009; 36:2049-2057
  80. Nakajima K, Okuda K, Kawano M, Matsuo S, Slomka P, Germano G, Kinuya S: The importance of population-specific normal database for quantification of myocardial ischemia: Comparison between Japanese 360 and 180-degree databases and a US database. J Nucl Cardiol 2009; 16:422-430
  81. Matsuo S, Nakajima K, Yamashina S, Sakata K, Momose M, Hashimoto J, Kumita S, Kawano M, Okuda K. Characterization of Japanese standards for myocardial sympathetic and metabolic imaging in comparison with perfusion imaging. Ann Nucl Med 2009; 23:517-522
  82. Okuda K, Nakajima K, Motomura N, Kubota M, Yamaki N, Maeda H, Matsuo S, Kinuya S. Attenuation correction of myocardial SPECT by scatter-photopeak window method in normal subjects. Ann Nucl Med 2009;23(5):501-6
  83. Momose M, Nakajima K, Nishimura T. Prognostic significance of stress myocardial gated SPECT among Japanese patients referred for coronary angiography: a study of data from the J-ACCESS database. Eur J Nucl Med Mol Imaging 2009; 36(8):1329-37
  84. Nakajima K, Kusuoka H, Nishimura S, Yamashina A, Nishimura T. Prognostic value of myocardial perfusion and ventricular function in a Japanese multicenter cohort study (J-ACCESS): the first-year total events and hard events Ann Nucl Med 2009; 23(4):373-81
  85. Kayano D, Nakajima K, Ohtake H, Kinuya S. Gated myocardial perfusion SPECT for preoperative risk stratification in patients with noncardiac vascular disease. Ann Nucl Med 2009; 23:173-81
  86. Matsuo S, Nakajima K, Okuda K, Kawano M, Ishikawa T, Hosoya T, Taki J, Kinuya S. Standardization of the heart-to-mediastinum ratio of iodine-123-labeled-meta-iodobenzylguanidine uptake using dual energy window method: Feasibility of correction from different camera-collimator combinations. Eur J Nucl Med Mol Imaging 2009; 36:560-566
  87. Kahara T, Nakajima K, Takahashi K, Iwaki N, Michigishi T, Usuda R. Accumulations in the salivary gland due to Tc-99m pertechnetate imaging improved after isotope therapy for Graves' disease. Intern Med. 2008;47(3):179-80. Epub 2008 Feb 1.
  88. Nakajima K, Yoshita M, Matsuo S, Taki J, Kinuya S. I-123 MIBG sympathetic imaging in Lewy-body diseases and related movement disorders. [Review] Q J Nucl Med 2008;52: 378-87.
  89. Nakajima K, Nishimura T. Prognostic table for predicting major cardiac events based on J-ACCESS investigation. Ann Nucl Med 2008; 22:891-897 [Heart Risk Table; sample figures]
  90. Kizu H, Takayama T, Tsushima H, Noguchi A, Nakajima K, Onoguchi M, Kinuya S. Localization of metastases from malignant pheochromocytoma in patients undergoing 131I-MIBG therapy with manually fused 123I-MIBG SPECT and CT images. J Nuc Med Tech 2008 36; 186-8
  91. Nakajima K, Tamaki N, Kuwabara Y, Kawano M, Matsunari I, Taki J, Nishimura S, Yamashina A, Ishida Y, Tomoike H. Prediction of functional recovery after revascularization using quantitative gated myocardial perfusion SPECT: a multi-center cohort study in Japan. Eur J Nucl Med Mol Imaging 2008; 35:2038-2048 [pubmed]
  92. Akhter N, Nakajima K, Okuda K, Matsuo S, Yoneyama T, Taki J, Kinuya S. Regional wall thickening in gated myocardial perfusion SPECT in a Japanese population: Effect of sex, radiotracer, rotation angles and frame rates. Eur J Nucl Med Mol Imaging 2008; 35: 1608-1615 [pubmed] [Springer]
  93. Matsuo S, Nakajima K, Horie M, Nakae I, Nishimura T; The J-ACCESS Investigators. Prognostic value of normal stress myocardial perfusion imaging in Japanese population. Circ J 2008;72(4):611-617 [pubmed]
  94. Nishimura T, Nakajima K, Kusuoka H, Yamashina A, Nishimura S. Prognostic study of risk stratification among Japanese patients with ischemic heart disease using gated myocardial perfusion SPECT: J-ACCESS study. Eur J Nucl Med Mol Imaging 2008; 35:19-28. [pubmed]
  95. Nakajima K, Matsubara K, Ishikawa T, Motomura N, Maeda R, Akhter N, Okuda K, Taki J, Kinuya S. Correction of I-123-labeled meta-iodobenzylguanidine uptake with multi-window methods for standardization of the heart to mediastinum ratio. J Nucl Cardiol 2007; 14:843-851. [pubmed]
  96. Nakajima K, Kumita S, Ishida Y, Momose M, Hashimoto J, Morita K, Taki J, Yamashina S, Maruno H, Ogawa M, Kubota M, Takahashi M, Odagawa T, Yokozuka K. Creation and characterization of Japanese standards for myocardial perfusion SPECT: Database from Japanese Society of Nuclear Medicine Working Group. Ann Nucl Med 2007; 21: 505-511 [Springer/ANM]
  97. Nakajima K, Kusuoka H, Nishimura S, Yamashina A, Nishimura T. Normal limits of ejection fraction and volumes by gated SPECT based on J-ACCESS database in clinically normal patients without cardiac events. Eur J Nucl Med Mol Imaging 2007;34: 1088-1096 [pubmed]
  98. Kusuoka H, Nishimura S, Yamashina A, Nakajima K, Nishimura T. Surveillance study for creating the national clinical database related to ECG-gated myocardial perfusion SPECT of ischemic heart disease: J-ACCESS study design. Ann Nucl Med 2006;20:195-202. [pubmed]
  99. Nakajima K, Kawano M, Hasegawa M, Taki J, Fujimoto M, Takehara K, Tonami N. Myocardial damages in systemic sclerosis detected by gated myocardial perfusion SPECT and sympathetic imaging. Circ J 2006;70:1481-1487 [pubmed]
  100. Nakajima K, Taki J, Yoneyama T, Fukuoka M, Kayano D, Tonami N. Fluctuation of adenosine concentration by modes of intravenous infusion based on mathematical simulation and experiments. Ann Nucl Med. 2006 ;20:485-91
  101. Nakajima K, Nishimura T. Inter-institution preference-based variability of ejection fraction and volumes using quantitative gated SPECT with 99mTc-tetrofosmin: a multicentre study involving 106 hospitals. Eur J Nucl Med Mol Imaging 2006; 33:127-133
  102. Nakajima K, Kawano M,Kinami S, Fujimura T, Miwa K, Tonami N. Dual-radionuclide simultaneous gastric emptying and bile transit study after gastric surgery with double-tract reconstruction. Ann Nucl Med 2005; 19:185-191
  103. Nakajima K, Kawano M, Kinuya K, Sato S, Takehara K, Tonami N. The diagnostic value of oesophageal transit scintigraphy for evaluating the severity of oesophageal complications in systemic sclerosis. Nucl Med Commun 2004;25:375-81. Keywords: esophageal transit study, systemic sclerosis, esophageal dysmotility [pubmed]
  104. Nakajima K, Higuchi T, Taki J, Kawano M, Tonami N. Accuracy of ventricular volume and ejection fraction measured by gated myocardial SPECT: Comparison of 4 software programs. J Nucl Med 2001;42:1571-1578
  105. Taki J, Fujino S, Nakajima K, Matsunari I, Okazaki H, Saga T, Bunko H, Tonami N. 99mTc-sestamibi retention characteristics during pharmacologic hyperemia in human myocardium: Comparison with coronary flow reserve measured by doppler flowire. J Nucl Med 2001;42:1457-1463
  106. Higuchi T, Nakajima K, Taki J, Kinuya S, Bunko H, Tonami N. Assessment of left ventricular systolic and diastolic function based on the edge detection method with myocardial ECG-gated SPET. Eur J Nucl Med 2001; 28:1512-1516
  107. Nakajima K, Taki J, Kawano M, Higuchi T, Sato S, Nishijima C, Takehara K, Tonami N. Diastolic dysfunction in patients with systemic sclerosis detected by gated myocardial perfusion SPECT: an early sign of cardiac involvement. J Nucl Med 2001;42:183-188.
  108. Nakajima K, Taki J, Higuchi T, Kawano M, Taniguchi M, Maruhashi, K, Sakazume S, Tonami N. Gated SPET quantification of small hearts: Mathematical simulation and clinical application. Eur J Nucl Med 2000;27:1372-1379
  109. Taki J, Nakajima K, Hwang EH, Matsunari I, Komai K, Yoshita M, Sakajiri K, Tonami N. Peripheral sympathetic dysfunction in patients with Parkinson's disease without autonomic failure is heart sensitive and disease specific. Eur J Nucl Med 2000; 27: 566-573
  110. Ikeda E, Taki J, Nakajima K, Tonami N. Thallium-201 SPECT with triple-headed gamma camera for differential diagnosis of small pulmonary nodular lesion 20 mm in diameter or smaller. Ann Nucl Med 2000; 14:91-95
  111. Taki J, Muramori A, Kinuya S, Nakajima K, Matsunari I, Miyazaki Y, Murata Y, Tonami N. Forward output measurement with first-pass technique using 99mTc-labeled myocardial perfusion imaging agent. J Nucl Med 1999; 40: 1874-1881
  112. Nakajima K, Kinuya K, Mizutani Y, Hwang EH, Michigishi T, Tonami N, Kobayashi K: Simple scintigraphic parameters with Tc-99m galactosyl human serum albumin for clinical staging of chronic hepatocellular dysfunction. Ann Nucl Med 1999; 13: 5-11
  113. Taki J, Matsunari I, Nakajima K, Tonami N. BMIPP compared with thallium redistribution. Int J Cardiac Imaging 1999; 15: 49-59
  114. Hwang EH, Taki J, Shuke N, Nakajima K, Kinuya S, Konishi S, Michigishi T, Aburano T, Tonami N. Preoperative assessment of residual hepatic functional reserve using 99mTc-DTPA-galactosyl-human serum albumin dynamic SPECT. J Nucl Med 1999; 40: 1644-1651
  115. Taki J, Yamamoto W, Nakajima K, Ichiyanagi K, Kato H, Furukawa M, Tonami N. Prediction of prognosis in peripheral nerve paralysis using submandibular gland scintigraphy. J Nucl Med 1998; 39: 716-721.
  116. Taki J, Yasuhara S, Takamatsu T, Nakajima K, Tatami R, Ishise S, Matsunari I, Takayama T, Tonami N. Value of iodine-123 metaiodobenzylguanidine scintigraphy in patients with vasospastic angina. Eur J Nucl Med 1998; 25: 229-234
  117. Hwang EH, Taki J, Yasue S, Fujimoto M, Taniguchi M, Matsunari I, Nakajima K, Shiobara S, Ikeda T, Tonami N. Absent myocardial iodine-123-BMIPP uptake and platelet/monocyte CD36 deficiency. J Nucl Med 1998; 39: 1681-1684
  118. Nakajima K, Taki J, Michigishi T, et al: Superiority of triple-detector SPET over single-and dual-detector systems in the minimization of motion artefacts. Eur J Nucl Med 1998; 25, 1545-1551
  119. Nakajima K, Taki J, Yamamoto W, et al: Myocardial fatty acid imaging with I-123 labelled 9-methyl-branched pentadecanoic acid (9MPA) using SPET. Nucl Med Commun 1998; 19:839-847
  120. Nakajima K, Taki J, Yamamoto W, et al: Effect of 360. and 180. rotation SPET acquisition on myocardial polar map: Comparison of 201Tl, 99Tcm- and 123I-labelled radiopharmaceuticals. Nucl Med Commun 1998; 19: 315-625
  121. Kuji I, Sumiya H, Taki J, Nakajima K, Yokoyama K, Kinuya S, Kinuya K, Ichikawa A, Konishi S, Michigishi T, Tonami N. Intense Ga-67 uptake in adenosquamous carcinoma of the pancreas. Ann Nucl Med 1997;11: 41-43
  122. Nakajima K, Taki J, Matsuyama T, et al: Functional imaging of gated Tc-99m tetrofosmin study as a simple method to quantify ventricular wall motion. Ann Nucl Med 1997; 11: 87-94
  123. Taki J, Nakajima K, Matsunari I, Bunko H, Takata S, Kawasuji M, Tonami N. Assessment of improvement of myocardial fatty acid uptake and function after revascularization using iodine-123-BMIPP. J Nucl Med 1997; 38: 1503-1510
  124. Taki J, Ichikawa A, Nakajima K, Kawasuji M, Tonami N. Comparison of flow capacities of arterial and venous grafts for coronary artery bypass grafting: evaluation with exercise thallium-201 single-photon emission tomography. Eur J Nucl Med 1997; 24: 1487-1493
  125. Nakajima K, Shuke N, Nitta Y, et al. Comparison of 99Tcm-pyrophosphate, 201T1 perfusion, 123I-labelled methyl-branched fatty acid and sympathetic imaging in acute coronary syndrome. Nucl Med Commun 1995; 16: 494-503.
  126. Nakajima K, Shimizu K, Taki J, et al. Utility of iodine-123-BMIPP in the diagnosis and follow-up of vasospastic angina. J Nucl Med 1995; 36: 1934-40.
  127. Nakajima K, Taki J, Tonami N and Hisada K. Decreased 123I-MIBG uptake and increased clearance in various cardiac diseases. Nucl Med Commun 1994; 15: 317-23.
  128. Taki J, Nakajima K, Matsunari I, et al. Impairment of regional fatty acid uptake in relation to wall motion and thallium-201 uptake in ischaemic but viable myocardium: assessment with iodine-123-labelled beta-methyl-branched fatty acid. Eur J Nucl Med 1995; 22: 1385-92.
  129. Taki J, Nakajima K, Shimizu M, Tonami N and Hisada K. Left ventricular functional reserve in nonobstructive hypertrophic cardiomyopathy: evaluation by continuous left ventricular function monitoring. J Nucl Med 1994; 35: 1937-43.
  130. Taki J, Nakajima K, Bunko H, et al. Twenty-four-hour quantitative thallium imaging for predicting beneficial revascularization. Eur J Nucl Med 1994; 21: 1212-7.
  131. Taki J, Nakajima K, Muramori A, et al. Left ventricular dysfunction during exercise in patients with angina pectoris and angiographically normal coronary arteries (syndrome X) [published erratum appears in Eur J Nucl Med 1994 Jul;21(7):712]. Eur J Nucl Med 1994; 21: 98-102.
  132. Nakajima K, Taki J, Shuke N, et al. Myocardial perfusion imaging and dynamic analysis with technetium-99m tetrofosmin. J Nucl Med 1993; 34: 1478-84.
  133. Nakajima K, Taki J, Matsudaira M, et al. High-resolution cardiac SPET study using fanbeam collimators in infants. Nucl Med Commun 1992; 13: 604-8.
  134. Nakajima K, Shuke N, Taki J, et al. A simulation of dynamic SPECT using radiopharmaceuticals with rapid clearance. J Nucl Med 1992; 33: 1200-6.
  135. Nakajima K, Taki J, Ohno T, et al. Assessment of right ventricular overload by a thallium-201 SPECT study in children with congenital heart disease. J Nucl Med 1991; 32: 2215-20.
  136. Nakajima K, Taki J, Bunko H, et al. Dynamic acquisition with a three-headed SPECT system: application to technetium 99m-SQ30217 myocardial imaging. J Nucl Med 1991; 32: 1273-7.
  137. Nakajima K, Taki J, Bunko H, et al. Error of uptake in dual energy acquisition with 201Tl and 123I labeled radiopharmaceuticals. Eur J Nucl Med 1990; 16: 595-9.
  138. Nakajima K, Fotouhi F, Taki J, et al. Estimation of right ventricular pressure by 201Tl scintigraphy in paediatric cardiac disease. Nucl Med Commun 1990; 11: 677-84.
  139. Nakajima K, Bunko H, Taki J, et al. Quantitative analysis of 123I-meta-iodobenzylguanidine (MIBG) uptake in hypertrophic cardiomyopathy. Am Heart J 1990; 119: 1329-37.
  140. Other works:

Update: Mar 16, 2018
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